1. Department of Toxicology, University of Cagliary, I-09126, Cagliary, Italy, Department of Pharmaceutical Sciences and Biotechnology Center and Department of Chemistry, University of Ferrara, I-44100 Ferrara, Italy, Department of Human Physiology and Pharmacology “Vittorio Erspamer,” University La Sapienza, I-00185 Rome, Italy, and Medicinal Chemistry Group, LCBRA, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709