Small Molecule STAT5-SH2 Domain Inhibitors Exhibit Potent Antileukemia Activity-Reference-Cited by-同舟云学术

Small Molecule STAT5-SH2 Domain Inhibitors Exhibit Potent Antileukemia Activity

Published:2012-01-13 Issue:3 Volume:55 Page:1047-1055
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Page Brent D. G.¹,Khoury Haytham²,Laister Rob C.²,Fletcher Steven¹,Vellozo Megan²,Manzoli Alessia²,Yue Peibin³,Turkson James³,Minden Mark D.²,Gunning Patrick T.¹

Affiliation:

1. Department of Chemistry, University of Toronto, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada

2. Princess Margaret Hospital, Ontario Cancer Institute, 610 University Avenue, Toronto, ON M5G 2M9, Canada

3. Department of Molecular Biology and Microbiology, Burnett College of Biomedical Sciences, University of Central Florida, Orlando, Florida 32826, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200720n

Reference26 articles.

1. Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches

2. Discovery of Chromone-Based Inhibitors of the Transcription Factor STAT5

3. Signal transducer and activator of transcription 3 inhibitors: a patent review

4. Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein

5. Inhibiting aberrant Stat3 function with molecular therapeutics

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