Optimization of 2-Phenylaminoimidazo[4,5-h]isoquinolin-9-ones: Orally Active Inhibitors of lck Kinase-Reference-Cited by-同舟云学术

Optimization of 2-Phenylaminoimidazo[4,5-h]isoquinolin-9-ones: Orally Active Inhibitors of lck Kinase

Published:2003-03-18 Issue:8 Volume:46 Page:1337-1349
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Goldberg Daniel R.¹,Butz Tanja¹,Cardozo Mario G.¹,Eckner Robert J.¹,Hammach Abdelhakim¹,Huang Jessica¹,Jakes Scott¹,Kapadia Suresh¹,Kashem Mohammed¹,Lukas Susan¹,Morwick Tina M.¹,Panzenbeck Maret¹,Patel Usha¹,Pav Susan¹,Peet Gregory W.¹,Peterson Jeffrey D.¹,Prokopowicz Anthony S.¹,Snow Roger J.¹,Sellati Rosemarie¹,Takahashi Hidenori¹,Tan Jonathan¹,Tschantz Matt A.¹,Wang Xiao-Jun¹,Wang Yong¹,Wolak John¹,Xiong Pla¹,Moss Neil¹

Affiliation:

1. Departments of Medicinal Chemistry, Biology, Chemical Development, and Pharmacology, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm020446l

Reference20 articles.

1. Receptor Tyrosine Kinases as Therapeutic Targets the Model of the MET Oncogene

2. T cell antigen receptor signal transduction

3. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

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