Discovery of (R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): A Potent Antagonist of the Human Calcitonin Gene-Related Peptide Receptor for Migraine with Rapid and Efficient Intranasal Exposure-Reference-Cited by-同舟云学术

Discovery of (R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): A Potent Antagonist of the Human Calcitonin Gene-Related Peptide Receptor for Migraine with Rapid and Efficient Intranasal Exposure

Published:2008-07-30 Issue:16 Volume:51 Page:4858-4861
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Degnan Andrew P.¹,Chaturvedula Prasad V.¹,Conway Charles M.¹,Cook Deborah A.¹,Davis Carl D.¹,Denton Rex¹,Han Xiaojun¹,Macci Robert¹,Mathias Neil R.¹,Moench Paul¹,Pin Sokhom S.¹,Ren Shelly X.¹,Schartman Richard¹,Signor Laura J.¹,Thalody George¹,Widmann Kimberly A.¹,Xu Cen¹,Macor John E.¹,Dubowchik Gene M.¹

Affiliation:

1. Departments of Neuroscience Chemistry, Neuroscience Biology, Metabolism and Phamacokinetics, Bioanalytical Research, Discovery Toxicology, Pharmaceutics, and Pharmaceutics Development, Bristol-Myers Squibb Research & Development, 5 Research Parkway, Wallingford, Connecticut 06492

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800546t

Reference30 articles.

1. MECHANISM OF MIGRAINE HEADACHE AND ACTION OF ERGOTAMINE TARTRATE

2. Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries: relationship to clinical effect

3. Migraine — Current Understanding and Treatment

4. Calcitonin Gene-Related Peptide Antagonists as Treatments of Migraine and Other Primary Headaches

5. Blockade of CGRP Receptors in the Intracranial Vasculature: A New Target in the Treatment of Headache

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