18F-Fluorination of Unactivated C–H Bonds in Branched Aliphatic Amino Acids: Direct Synthesis of Oncological Positron Emission Tomography Imaging Agents

Author:

Nodwell Matthew B.1,Yang Hua2,Čolović Milena3,Yuan Zheliang12,Merkens Helen3,Martin Rainer E.4ORCID,Bénard François3,Schaffer Paul12,Britton Robert1ORCID

Affiliation:

1. Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S2, Canada

2. Life Sciences Division, TRIUMF, Vancouver, British Columbia V6T 2A3, Canada

3. Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3 Canada

4. Medicinal Chemistry, Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel, Switzerland

Funder

F. Hoffmann-La Roche

Natural Sciences and Engineering Research Council of Canada

Canadian Cancer Society Research Institute

Michael Smith Foundation for Health Research

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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