The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting of Both Structures by Small Molecules To Downregulate Gene Expression-Reference-Cited by-同舟云学术

The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting of Both Structures by Small Molecules To Downregulate Gene Expression

Published:2017-05-19 Issue:22 Volume:139 Page:7456-7475
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Brown Robert V.¹,Wang Ting²,Chappeta Venkateshwar Reddy¹,Wu Guanhui¹,Onel Buket¹,Chawla Reena³,Quijada Hector²,Camp Sara M.²,Chiang Eddie T.²,Lassiter Quinea R.⁴,Lee Carmen⁴⁵,Phanse Shivani⁵,Turnidge Megan A.⁵,Zhao Ping⁶,Garcia Joe G. N.²,Gokhale Vijay¹³,Yang Danzhou¹³⁷,Hurley Laurence H.¹³⁷^ORCID

Affiliation:

1. College of Pharmacy, University of Arizona, 1703 East Mabel Street, Tucson, Arizona 85721, United States

2. College of Medicine, University of Arizona, 1501 North Campbell Avenue, Tucson, Arizona 85724, United States

3. BIO5 Institute, 1657 East Helen Street, Tucson, Arizona 85721, United States

4. College of Agriculture & Life Sciences, University of Arizona, 1117 East Lowell Street, Tucson, Arizona 85721, United States

5. College of Science, University of Arizona, 1040 East Fourth Street, Tucson, Arizona 85721, United States

6. School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, No. 280 Waihuandong Road, Education Mega Centre, Guanzhou 510006, Peoples Republic of China

7. University of Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, Arizona 85724, United States

Funder

National Cancer Institute

National Heart, Lung, and Blood Institute

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.6b10028

Reference82 articles.

1. Role of platelet-derived growth factors in physiology and medicine