Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors-Reference-Cited by-同舟云学术

Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors

Published:2017-02-22 Issue:9 Volume:139 Page:3417-3429
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Spagnuolo Lauren A.¹,Eltschkner Sandra²,Yu Weixuan¹,Daryaee Fereidoon¹,Davoodi Shabnam¹,Knudson Susan E.³,Allen Eleanor K. H.¹,Merino Jonathan¹,Pschibul Annica²,Moree Ben⁴,Thivalapill Neil⁵,Truglio James J.⁵,Salafsky Joshua⁴,Slayden Richard A.³,Kisker Caroline²,Tonge Peter J.¹^ORCID

Affiliation:

1. Institute of Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States

2. Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Würzburg, 97080 Würzburg, Germany

3. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523-2025, United States

4. Biodesy, Inc., 384 Oyster Point Boulevard, South San Francisco, California 94080, United States

5. Great Neck South High School, 341 Lakeville Road, Great Neck, New York 11020, United States

Funder

Deutsche Forschungsgemeinschaft

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.6b11148

Reference42 articles.

1. The drug–target residence time model: a 10-year retrospective

2. Drug–target residence time and its implications for lead optimization

3. Drug–target residence time: critical information for lead optimization

4. Translating slow-binding inhibition kinetics into cellular and in vivo effects

5. Design strategies to address kinetics of drug binding and residence time

Cited by 45 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Identification of antimycobacterial 8-hydroxyquinoline derivatives as in vitro enzymatic inhibitors of Mycobacterium tuberculosis enoyl-acyl carrier protein reductase;Bioorganic Chemistry;2024-10

2. Accurate Characterization of Binding Kinetics and Allosteric Mechanisms for the HSP90 Chaperone Inhibitors Using AI-Augmented Integrative Biophysical Studies;JACS Au;2024-04-01

3. Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA;European Journal of Medicinal Chemistry;2023-11

4. The translational value of ligand‐receptor binding kinetics in drug discovery;British Journal of Pharmacology;2023-09-30

5. Evaluating the Impact of the Tyr158 pK_a on the Mechanism and Inhibition of InhA, the Enoyl-ACP Reductase from Mycobacterium tuberculosis;Biochemistry;2023-06-04