Design, Synthesis, and Structure−Activity Relationship of Substrate Competitive, Selective, and in Vivo Active Triazole and Thiadiazole Inhibitors of the c-Jun N-Terminal Kinase-Reference-Cited by-同舟云学术

Design, Synthesis, and Structure−Activity Relationship of Substrate Competitive, Selective, and in Vivo Active Triazole and Thiadiazole Inhibitors of the c-Jun N-Terminal Kinase

Published:2009-03-09 Issue:7 Volume:52 Page:1943-1952
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

De Surya K.¹,Stebbins John L.¹,Chen Li-Hsing¹,Riel-Mehan Megan¹,Machleidt Thomas¹,Dahl Russell¹,Yuan Hongbin¹,Emdadi Aras¹,Barile Elisa¹,Chen Vida¹,Murphy Ria¹,Pellecchia Maurizio¹

Affiliation:

1. Infectious and Inflammatory Disease Center and Cancer Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, and Invitrogen Discovery Services, Invitrogen Corporation, 501 Charmany Drive, Madison, Wisconsin 53719

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801503n

Reference30 articles.

1. The Protein Kinase Complement of the Human Genome

2. Targeting JNK for therapeutic benefit: from junk to gold?

3. Therapeutic promise of JNK ATP-noncompetitive inhibitors

4. Selective interaction of JNK protein kinase isoforms with transcription factors.

5. Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

Cited by 78 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Covalent small-molecule inhibitors of SARS-CoV-2 Mpro: Insights into their design, classification, biological activity, and binding interactions;European Journal of Medicinal Chemistry;2024-11

2. Discovery of Piperazin‐2‐yl‐pyrimidines as Anticancer Agents via Targeting JNK Signaling Pathway in Human MCF‐7 Breast Carcinoma;ChemistrySelect;2024-07-17

3. 5,5′-Thiobis(3-bromoisothiazole-4-carbonitrile);Molbank;2024-04-24

4. The Role of the Dysregulated JNK Signaling Pathway in the Pathogenesis of Human Diseases and Its Potential Therapeutic Strategies: A Comprehensive Review;Biomolecules;2024-02-19

5. Deep learning approach to the discovery of novel bisbenzazole derivatives for antimicrobial effect;Journal of Molecular Structure;2024-01