Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases: Synthesis, Structure–Activity Relationship, and Selective Antitumor Activity-Reference-Cited by-同舟云学术

Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases: Synthesis, Structure–Activity Relationship, and Selective Antitumor Activity

Published:2014-10-01 Issue:20 Volume:57 Page:8307-8318
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Zhen,Yao Yuan,Kogiso Mari,Zheng Baisong,Deng Lisheng,Qiu Jihui J.,Dong Shuo,Lv Hua¹,Gallo James M.¹,Li Xiao-Nan,Song Yongcheng

Affiliation:

1. Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, New York 10029, United States

Funder

National Institute of Neurological Disorders and Stroke

National Cancer Institute

Cancer Prevention and Research Institute of Texas

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500660f

Reference41 articles.

1. Structures of Human Cytosolic NADP-dependent Isocitrate Dehydrogenase Reveal a Novel Self-regulatory Mechanism of Activity

2. Function and expression of yeast mitochondrial NAD- and NADP-specific isocitrate dehydrogenases

3. Cytosolic NADP(+)-dependent isocitrate dehydrogenase. Isolation of rat cDNA and study of tissue-specific and developmental expression of mRNA.

4. An Integrated Genomic Analysis of Human Glioblastoma Multiforme

5. Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

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