Amyloid-α Peptide Formed through Alternative Processing of the Amyloid Precursor Protein Attenuates Alzheimer’s Amyloid-β Toxicity via Cross-Chaperoning

Author:

Kuhn Ariel J.1,Chan Ka1,Sajimon Maria1ORCID,Yoo Stan2,Balasco Serrão Vitor Hugo3,Lee Jack1,Abrams Benjamin4,Nowick James S.2ORCID,Uversky Vladimir N.5ORCID,Wheeler Christopher678910,Raskatov Jevgenij A.1ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, California 95064, United States

2. Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, United States

3. Biomolecular Cryoelectron Microscopy Facility, University of California, Santa Cruz, Santa Cruz, California 95064, United States

4. Department of Biomolecular Engineering, Life Sciences Microscopy Center, University of California, Santa Cruz, Santa Cruz, California 95064, United States

5. Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, MDC07, Tampa, Florida 33612, United States

6. World Brain Mapping Foundation, Society for Brain Mapping & Therapeutics, 860 Via De La Paz, Suite E-1, Pacific Palisades, California 90272-3668, United States

7. StemVax Therapeutics (Subsidiary of NovAccess Global), 8584 E. Washington Street #127, Chagrin Falls, Ohio 44023, United States

8. StemVax Therapeutics (Subsidiary of NovAccess Global), 2265 E. Foothill Boulevard, Pasadena, California 91107, United States

9. T-Neuro Pharma, 1451 Innovation Parkway SE, Suite 600, Albuquerque, New Mexico 87123, United States

10. T-Neuro Pharma, P.O. Box 781, Aptos, California 95003, United States

Funder

National Institute on Aging

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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