Identification and Development of Cyclic Peptide Inhibitors of Hypoxia Inducible Factors 1 and 2 That Disrupt Hypoxia-Response Signaling in Cancer Cells
Author:
Affiliation:
1. School of Chemistry, University of Southampton, Southampton SO17 1BJ, U.K.
2. Discovery Sciences IMED Biotech Unit, AstraZeneca, 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U.K.
Funder
AstraZeneca
Engineering and Physical Sciences Research Council
Cancer Research UK
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/jacs.3c10508
Reference52 articles.
1. Physiological and Pathological Responses to Hypoxia
2. Hypoxia in cancer: significance and impact on clinical outcome
3. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
4. Investigating hypoxic tumor physiology through gene expression patterns
5. Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization
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