Trinucleotide mRNA Cap Analogue N6-Benzylated at the Site of Posttranscriptional m6Am Mark Facilitates mRNA Purification and Confers Superior Translational Properties In Vitro and In Vivo-Reference-Cited by-同舟云学术

Trinucleotide mRNA Cap Analogue N6-Benzylated at the Site of Posttranscriptional ^m6A_m Mark Facilitates mRNA Purification and Confers Superior Translational Properties In Vitro and In Vivo

Published:2024-03-05 Issue:12 Volume:146 Page:8149-8163
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Warminski Marcin¹^ORCID,Trepkowska Edyta²,Smietanski Miroslaw²,Sikorski Pawel J.³⁴^ORCID,Baranowski Marek R.²^ORCID,Bednarczyk Marcelina³²^ORCID,Kedzierska Hanna²,Majewski Bartosz²,Mamot Adam³,Papiernik Diana²,Popielec Agnieszka²,Serwa Remigiusz A.⁵,Shimanski Brittany A.⁶,Sklepkiewicz Piotr²,Sklucka Marta²,Sokolowska Olga²,Spiewla Tomasz¹²,Toczydlowska-Socha Diana²,Warminska Zofia³,Wolosewicz Karol²,Zuberek Joanna¹,Mugridge Jeffrey S.⁶,Nowis Dominika²⁷,Golab Jakub²⁷,Jemielity Jacek³²^ORCID,Kowalska Joanna¹²^ORCID

Affiliation:

1. Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, 02-089 Warsaw, Poland

2. Explorna Therapeutics sp. z o.o. Zwirki i Wigury 93, 02-089 Warsaw, Poland

3. Centre of New Technologies, University of Warsaw, 02-089 Warsaw, Poland

4. Laboratory of Epitranscriptomics, Department of Environmental Microbiology and Biotechnology, Institute of Microbiology, Faculty of Biology, Biological and Chemical Research Centre, University of Warsaw, 02-089 Warsaw, Poland

5. Proteomics Core Facility, IMol Polish Academy of Sciences, 02-247 Warsaw, Poland

6. Department of Chemistry & Biochemistry, University of Delaware, Newark, Delaware 19716, United States

7. Laboratory of Experimental Medicine, Faculty of Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland

Funder

European Regional Development Fund

Narodowe Centrum Nauki

Narodowe Centrum Badan i Rozwoju

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.3c12629

Reference76 articles.