Piperazine-Fused Cyclic Disulfides Unlock High-Performance Bioreductive Probes of Thioredoxins and Bifunctional Reagents for Thiol Redox Biology-Reference-Cited by-同舟云学术

Piperazine-Fused Cyclic Disulfides Unlock High-Performance Bioreductive Probes of Thioredoxins and Bifunctional Reagents for Thiol Redox Biology

Published:2024-02-15 Issue:8 Volume:146 Page:5204-5214
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Zeisel Lukas¹^ORCID,Felber Jan G.¹^ORCID,Scholzen Karoline C.²^ORCID,Schmitt Carina¹,Wiegand Alexander J.¹,Komissarov Leonid³^ORCID,Arnér Elias S.J.²⁴^ORCID,Thorn-Seshold Oliver¹^ORCID

Affiliation:

1. Department of Pharmacy, LMU Munich, Butenandtstr. 5-13, Munich 81377, Germany

2. Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden

3. Center for Molecular Modeling (CMM), Ghent University, Technologiepark-Zwijnaarde 46, Ghent 9052, Belgium

4. Department of Selenoprotein Research, National Institute of Oncology, Budapest 1122, Hungary

Funder

Bundesministerium f?r Bildung und Forschung

Vetenskapsr?det

National Research, Development and Innovation Office

Center for NanoScience, Ludwig-Maximilians-Universit?t M?nchen

Deutsche Forschungsgemeinschaft

Knut och Alice Wallenbergs Stiftelse

Nemzeti Kutat?si Fejleszt?si ?s Innov?ci?s Hivatal

Emberi Eroforr?sok Miniszt?riuma

Horizon 2020 Framework Programme

Cancerfonden

Karolinska Institutet

Hungarian National Laboratories Excellence program

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.3c11153

Reference38 articles.

1. Physiological functions of thioredoxin and thioredoxin reductase

2. Glutaredoxins: Glutathione-Dependent Redox Enzymes with Functions Far Beyond a Simple Thioredoxin Backup System

3. The Redox Code

4. Selective cellular probes for mammalian thioredoxin reductase TrxR1: Rational design of RX1, a modular 1,2-thiaselenane redox probe

5. Thioredoxin redox control of cell growth and death and the effects of inhibitors

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