Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity-Reference-Cited by-同舟云学术

Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity

Published:2020-06-24 Issue:28 Volume:142 Page:12020-12026
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Panyain Nattawadee¹,Godinat Aurélien¹,Lanyon-Hogg Thomas¹^ORCID,Lachiondo-Ortega Sofía¹,Will Edward J.¹^ORCID,Soudy Christelle²,Mondal Milon¹,Mason Katie³,Elkhalifa Sarah³,Smith Lisa M.³,Harrigan Jeanine A.³,Tate Edward W.¹²^ORCID

Affiliation:

1. Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, W12 0BZ, U.K.

2. The Francis Crick Institute, London, NW1 1AT, U.K.

3. Mission Therapeutics Ltd, Moneta, Babraham Research Campus, Cambridge, CB22 3AT, U.K.

Funder

Medical Research Council

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

Wellcome Trust

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

http://pubs.acs.org/doi/pdf/10.1021/jacs.0c04527

Reference31 articles.

1. Deubiquitylating enzymes and drug discovery: emerging opportunities

2. Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights

3. Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells

4. Recent Developments in Cell Permeable Deubiquitinating Enzyme Activity-Based Probes

5. Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction

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