Do Aptamers Always Bind? The Need for a Multifaceted Analytical Approach When Demonstrating Binding Affinity between Aptamer and Low Molecular Weight Compounds-Reference-Cited by-同舟云学术

Do Aptamers Always Bind? The Need for a Multifaceted Analytical Approach When Demonstrating Binding Affinity between Aptamer and Low Molecular Weight Compounds

Published:2020-11-09 Issue:46 Volume:142 Page:19622-19630
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Bottari Fabio¹^ORCID,Daems Elise¹²^ORCID,de Vries Anne-Mare³⁴,Van Wielendaele Pieter⁵,Trashin Stanislav¹^ORCID,Blust Ronny⁶,Sobott Frank²⁷^ORCID,Madder Annemieke⁴^ORCID,Martins José C.³,De Wael Karolien¹^ORCID

Affiliation:

1. AXES Research Group, Department of Bioscience Engineering, University of Antwerp, Antwerp, 2020, Belgium

2. BAMS Research Group, Department of Chemistry, University of Antwerp, Antwerp, 2020, Belgium

3. NMR and Structure Analysis Research Group, Department of Organic and Macromolecular Chemistry, Ghent University, Ghent, 9000, Belgium

4. Organic and Biomimetic Chemistry Research Group, Department of Organic and Macromolecular Chemistry, Ghent University, Ghent, 9000, Belgium

5. Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, 2610, Belgium

6. Sphere Research Group, Department of Biology, University of Antwerp, Antwerp, 2020, Belgium

7. Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom

Funder

Fonds Wetenschappelijk Onderzoek

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.0c08691

Reference63 articles.

1. In vitro selection of RNA molecules that bind specific ligands

2. Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

3. Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

4. Replacing antibodies with aptamers in lateral flow immunoassay

5. Advances in the development of aptamer drug conjugates for targeted drug delivery

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