Effects of N-Terminal Residues on the Assembly of Constrained β-Hairpin Peptides Derived from Aβ-Reference-Cited by-同舟云学术

Effects of N-Terminal Residues on the Assembly of Constrained β-Hairpin Peptides Derived from Aβ

Published:2020-06-05 Issue:26 Volume:142 Page:11593-11601
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Samdin Tuan D.¹^ORCID,Wierzbicki Michał¹^ORCID,Kreutzer Adam G.¹^ORCID,Howitz William J.¹^ORCID,Valenzuela Mike¹,Smith Alberto¹^ORCID,Sahrai Victoria¹^ORCID,Truex Nicholas L.¹^ORCID,Klun Matthew¹,Nowick James S.¹²^ORCID

Affiliation:

1. Department of Chemistry, University of California, Irvine, California 92697-2025, United States

2. Department of Pharmaceutical Sciences, University of California, Irvine Irvine, California 92697-2025, United States

Funder

Ministerstwo Nauki i Szkolnictwa Wyzszego

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.0c05186

Reference43 articles.

1. N-Terminal Hypothesis for Alzheimer’s Disease

2. Bioinorganic Chemistry of Alzheimer’s Disease

3. His6, His13, and His14 residues in Aβ 1–40 peptide significantly and specifically affect oligomeric equilibria

4. Side-chain moieties from the N-terminal region of Aβ are Involved in an oligomer-stabilizing network of interactions

5. pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicity

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