Incorporation of an Amide into 5-Phosphonoalkyl-6-d-ribitylaminopyrimidinedione Lumazine Synthase Inhibitors Results in an Unexpected Reversal of Selectivity for Riboflavin Synthase vs Lumazine Synthase-Reference-Cited by-同舟云学术

Incorporation of an Amide into 5-Phosphonoalkyl-6-d-ribitylaminopyrimidinedione Lumazine Synthase Inhibitors Results in an Unexpected Reversal of Selectivity for Riboflavin Synthase vs Lumazine Synthase

Published:2002-09-07 Issue:20 Volume:67 Page:6871-6877
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Cushman Mark¹,Yang Donglai¹,Mihalic Jeffrey T.¹,Chen Jinhua¹,Gerhardt Stefan¹,Huber Robert¹,Fischer Markus¹,Kis Klaus¹,Bacher Adelbert¹

Affiliation:

1. Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, Lehrstuhl für Organische Chemie und Biochemie, Technische Universität München, D-85747 Garching, Germany, and Max-Planck-Institut für Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D-82152 Martinsried, Germany

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo020144r

Reference27 articles.

1. Stereospecificity of the enzymic synthesis of the o-xylene ring of riboflavin

2. Bacher, A.; Eberhardt, S.; Richter, G. InEscherichia coli and Salmonella: Cellular and Molecular Biology, 2nd ed.; Neidhardt, F. C., Ed.; ASM Press: Washington, DC, 1996; pp 657−664.

3. Biosynthesis of Riboflavin: Structure and mechanism of lumazine synthase

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