1. Department of Pharmacology and Anaesthesiology, University of Padova, Italy, Department of Neurosciences, University of Siena, Italy, Department of Pharmaceutical Sciences, University of Bologna, Italy, Department of Pharmacology, School of Medicine, University Autonoma of Madrid, Spain, and Department of Pharmacology and Toxicology, Institute of Pharmacy, Center of Molecular Biosciences, University of Innsbruck, Austria