Insight into the Coupling Mechanism of the Vitamin K-Dependent Carboxylase: Mutation of Histidine 160 Disrupts Glutamic Acid Carbanion Formation and Efficient Coupling of Vitamin K Epoxidation to Glutamic Acid Carboxylation-Reference-Cited by-同舟云学术

Insight into the Coupling Mechanism of the Vitamin K-Dependent Carboxylase: Mutation of Histidine 160 Disrupts Glutamic Acid Carbanion Formation and Efficient Coupling of Vitamin K Epoxidation to Glutamic Acid Carboxylation

Published:2008-08-22 Issue:37 Volume:47 Page:9836-9846
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Rishavy Mark A.¹,Berkner Kathleen L.¹

Affiliation:

1. Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, 9500 Euclid Avenue, Cleveland, Ohio 44195

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi800296r

Reference47 articles.

1. THE VITAMIN K–DEPENDENT CARBOXYLASE

2. Vitamin K-Dependent Biosynthesis of γ-Carboxyglutamic Acid

3. Tethered Processivity of the Vitamin K-Dependent Carboxylase: Factor IX Is Efficiently Modified in a Mechanism Which Distinguishes Gla's from Glu's and Which Accounts for Comprehensive Carboxylation in Vivo

4. Processive Post-translational Modification

5. Vitamin K-dependent carboxylase. Control of enzyme activity by the “propeptide” region of factor X.

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