3-Aminopyrrolidinone Farnesyltransferase Inhibitors: Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency-Reference-Cited by-同舟云学术

3-Aminopyrrolidinone Farnesyltransferase Inhibitors: Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency

Published:2002-05-03 Issue:12 Volume:45 Page:2388-2409
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bell Ian M.¹,Gallicchio Steven N.¹,Abrams Marc¹,Beese Lorena S.¹,Beshore Douglas C.¹,Bhimnathwala Hema¹,Bogusky Michael J.¹,Buser Carolyn A.¹,Culberson J. Christopher¹,Davide Joseph¹,Ellis-Hutchings Michelle¹,Fernandes Christine¹,Gibbs Jackson B.¹,Graham Samuel L.¹,Hamilton Kelly A.¹,Hartman George D.¹,Heimbrook David C.¹,Homnick Carl F.¹,Huber Hans E.¹,Huff Joel R.¹,Kassahun Kelem¹,Koblan Kenneth S.¹,Kohl Nancy E.¹,Lobell Robert B.¹,Lynch, Joseph J.¹,Robinson Ronald¹,Rodrigues A. David¹,Taylor Jeffrey S.¹,Walsh Eileen S.¹,Williams Theresa M.¹,Zartman C. Blair¹

Affiliation:

1. Departments of Medicinal Chemistry, Cancer Research, Molecular Systems, Drug Metabolism, and Pharmacology, Merck Research Laboratories, West Point, Pennsylvania 19486, and Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm010531d

Reference21 articles.

1. p21ras is modified by a farnesyl isoprenoid.

2. Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.

3. Inhibitors of protein prenylation 1999

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