Asymmetric Synthesis of 2,3-Dihydro-2-arylquinazolin-4-ones: Methodology and Application to a Potent Fluorescent Tubulin Inhibitor with Anticancer Activity-Reference-Cited by-同舟云学术

Asymmetric Synthesis of 2,3-Dihydro-2-arylquinazolin-4-ones: Methodology and Application to a Potent Fluorescent Tubulin Inhibitor with Anticancer Activity

Published:2008-07-09 Issue:15 Volume:51 Page:4620-4631
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chinigo Gary M.¹,Paige Mikell¹,Grindrod Scott¹,Hamel Ernest¹,Dakshanamurthy Sivanesan¹,Chruszcz Maksymilian¹,Minor Wladek¹,Brown Milton L.¹

Affiliation:

1. Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, and Department of Oncology, Drug Discovery Program, Georgetown University Medical Center,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800271c

Reference24 articles.

1. Antibacterial 2,3-dihydro-2-(5-nitro-2-thienyl)quinazolin-4-(1H)-ones

2. 1-Aminoacyl-2,3-dihydro-4(1H)-quinazolinone derivatives with choleretic and antifibrillatory activity

3. The synthesis of 2,3-dihydro-4(1H)-quinazolinone angiotensin II receptor antagonists

4. 4-Oxo-1,2,3,4-tetrahydroquinazolines. I. Syntheses and pharmacological properties of 2-methyl-3-aryl-4-oxo-1,2,3,4-tetrahydroquinazolines and their 1-acyl derivatives

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