1. Medicinal Chemistry Research Laboratories, ‡Pharmacology Research Laboratories, ⊥DMPK Research Laboratories, #Product Quality Assurance Department, §Research Strategy & Planning Department, and ▼Tanabe R&D Service Synthetic Chemistry Department, Mitsubishi Tanabe Pharma Corporation, 2-2-50 Kawagishi, Toda, Saitama 335-8505, Japan