Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket-Reference-Cited by-同舟云学术

Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

Published:2013-04-02 Issue:5 Volume:57 Page:1790-1801
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gising Johan¹,Belfrage Anna Karin¹,Alogheli Hiba¹,Ehrenberg Angelica²,Åkerblom Eva¹,Svensson Richard³⁴,Artursson Per³⁴,Karlén Anders¹,Danielson U. Helena²,Larhed Mats¹,Sandström Anja¹

Affiliation:

1. Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, BMC, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden

2. Department of Chemistry, BMC, Uppsala University, BMC, Box 576, SE-751 23 Uppsala, Sweden

3. Department of Pharmacy, Uppsala University, Box 580, SE-751 23 Uppsala, Sweden

4. The Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Chemical Biology Consortium Sweden (CBCS), Uppsala University, Box 580, SE-751 23 Uppsala, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301887f

Reference55 articles.

1. Introduction: A smouldering public-health crisis

2. Hepatitis C: Fact Sheet no. 164;World Health Organization:Geneva,June, 2011.

3. Vaccines: A moving target

4. Directly acting antivirals against hepatitis C virus

5. Treatment of Chronic Hepatitis C Infection with Peginterferons Plus Ribavirin

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