Site-Specific PEGylated Exendin-4 Modified with a High Molecular Weight Trimeric PEG Reduces Steric Hindrance and Increases Type 2 Antidiabetic Therapeutic Effects-Reference-Cited by-同舟云学术

Site-Specific PEGylated Exendin-4 Modified with a High Molecular Weight Trimeric PEG Reduces Steric Hindrance and Increases Type 2 Antidiabetic Therapeutic Effects

Published:2012-11-09 Issue:11 Volume:23 Page:2214-2220
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Kim Tae Hyung¹,Jiang Hai Hua¹,Lim Sung Mook¹,Youn Yu Seok¹,Choi Ki Young²,Lee Seulki²,Chen Xiaoyuan²,Byun Youngro³,Lee Kang Choon¹

Affiliation:

1. College of Pharmacy, SungKyunKwan University, 300 Chonchon-dong, Jangan-ku, Suwon City 440-746, Korea

2. Laboratory of Molecular Imaging and Nanomedicine, NIBIB, NIH, Bethesda, Maryland 20892, United States

3. College of Pharmacy, Seoul National University, Seoul 151-742, Korea

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/bc300265n

Reference25 articles.

1. The conjugation of proteins with polyethylene glycol and other polymers

2. Improvement of pharmacokinetic, immunological and stability properties of asparaginase by conjugation to linear and branched monomethoxy poly( ethylene glycol)

3. Emerging PEGylated drugs

4. Rational Design of a Potent, Long-Lasting Form of Interferon: A 40 kDa Branched Polyethylene Glycol-Conjugated Interferon α-2a for the Treatment of Hepatitis C

5. Pegvisomant in the treatment of acromegaly

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