Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets-Reference-Cited by-同舟云学术

Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets

Published:2023-10-24 Issue:44 Volume:145 Page:24035-24051
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Ohta Atsushi¹,Tanada Mikimasa¹^ORCID,Shinohara Shojiro¹,Morita Yuya¹,Nakano Kazuhiko¹,Yamagishi Yusuke¹,Takano Ryusuke¹^ORCID,Kariyuki Shiori¹,Iida Takeo¹,Matsuo Atsushi¹,Ozeki Kazuhisa¹,Emura Takashi¹,Sakurai Yuuji¹,Takano Koji¹,Higashida Atsuko¹,Kojima Miki¹,Muraoka Terushige¹,Takeyama Ryuuichi¹,Kato Tatsuya¹,Kimura Kaori¹,Ogawa Kotaro¹,Ohara Kazuhiro¹,Tanaka Shota¹,Kikuchi Yasufumi¹,Hisada Nozomi¹,Hayashi Ryuji¹,Nishimura Yoshikazu¹^ORCID,Nomura Kenichi¹^ORCID,Tachibana Tatsuhiko¹,Irie Machiko¹,Kawada Hatsuo¹,Torizawa Takuya¹,Murao Naoaki¹,Kotake Tomoya¹,Tanaka Masahiko¹,Ishikawa Shiho¹,Miyake Taiji¹,Tamiya Minoru¹,Arai Masako¹,Chiyoda Aya¹,Akai Sho¹,Sase Hitoshi¹,Kuramoto Shino¹,Ito Toshiya¹^ORCID,Shiraishi Takuya¹,Kojima Tetsuo¹,Iikura Hitoshi¹

Affiliation:

1. Research Division, Chugai Pharmaceutical Co., Ltd., 216, Totsuka-cho,Totsuka-ku, Yokohama 244-8602, Kanagawa, Japan

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.3c07145

Reference61 articles.

1. Phage-encoded combinatorial chemical libraries based on bicyclic peptides

2. mRNA display: from basic principles to macrocycle drug discovery

3. RNA Display Methods for the Discovery of Bioactive Macrocycles

4. Two Decades under the Influence of the Rule of Five and the Changing Properties of Approved Oral Drugs

5. Reaching for high-hanging fruit in drug discovery at protein–protein interfaces

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