NMR Characterization of the Papain-like Protease from SARS-CoV-2 Identifies the Conformational Heterogeneity in Its Inhibitor-Binding Site-Reference-Cited by-同舟云学术

NMR Characterization of the Papain-like Protease from SARS-CoV-2 Identifies the Conformational Heterogeneity in Its Inhibitor-Binding Site

Published:2023-07-21 Issue:30 Volume:145 Page:16669-16677
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Shiraishi Yutaro¹^ORCID,Shimada Ichio¹²^ORCID

Affiliation:

1. Laboratory for Dynamic Structure of Biomolecules, RIKEN Center for Biosystems Dynamics Research (BDR), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

2. Graduate School of Integrated Sciences for Life, Hiroshima University, 1-4-4, Kagamiyama, Higashi-Hiroshima 739-8528, Japan

Funder

RIKEN

Japan Agency for Medical Research and Development

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.3c04115

Reference37 articles.

1. The pandemic’s true death toll: millions more than official counts

2. Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape

3. A tale of two antiviral targets — and the COVID-19 drugs that bind them

4. A Novel Coronavirus from Patients with Pneumonia in China, 2019

5. Nirmatrelvir Plus Ritonavir: First Approval

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1. Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape;Nature Communications;2024-07-23

2. Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PL^pro);ACS Medicinal Chemistry Letters;2024-07-23

3. Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19;2024-04-04

4. Mutational Profiling of SARS-CoV-2 PLpro in human cells reveals requirements for function, structure, and drug escape;2024-03-12