Lysine-Reactive <i>N</i>-Acyl-<i>N</i>-aryl Sulfonamide Warheads: Improved Reaction Properties and Application in the Covalent Inhibition of an Ibrutinib-Resistant BTK Mutant-Reference-Cited by-同舟云学术

Lysine-Reactive N-Acyl-N-aryl Sulfonamide Warheads: Improved Reaction Properties and Application in the Covalent Inhibition of an Ibrutinib-Resistant BTK Mutant

Published:2023-11-21 Issue:48 Volume:145 Page:26202-26212
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Kawano Masaharu¹,Murakawa Syunsuke¹,Higashiguchi Kenji¹^ORCID,Matsuda Kenji¹²^ORCID,Tamura Tomonori¹^ORCID,Hamachi Itaru¹³^ORCID

Affiliation:

1. Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan

2. Fukui Institute for Fundamental Chemistry, Kyoto University, Sakyo-ku, Kyoto 606-8103, Japan

3. ERATO (Exploratory Research for Advanced Technology, JST), Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan

Funder

Exploratory Research for Advanced Technology

Japan Science and Technology Agency

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.3c08740