Edge Length-Programmed Single-Stranded RNA Origami for Predictive Innate Immune Activation and Therapy

Author:

Dai Kun1,Xu Yang2,Yang Yang3,Shen Jianfeng4,Liu Xiaoguo1ORCID,Tu Xinyi2,Yu Lu2ORCID,Qi Xiaodong2ORCID,Li Jiang5ORCID,Wang Lihua5ORCID,Zuo Xiaolei6,Liu Yingbin3,Yan Hao2ORCID,Fan Chunhai1ORCID,Yao Guangbao1ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhangjiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China

2. School of Molecular Sciences and Biodesign Center for Molecular Design and Biomimetics, Biodesign Institute, Arizona State University, Tempe, Arizona 85287, United States

3. State Key Laboratory of Oncogenes and Related Genes, Department of Biliary-Pancreatic Surgery, Renji Hospital Affliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

4. Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Department of Ophthalmology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

5. Institute of Materiobiology, Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, China

6. Institute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acids Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

Funder

National Key Research and Development Program of China

Arizona State University

Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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