Towards Absolute Quantification of Therapeutic Monoclonal Antibody in Serum by LC−MS/MS Using Isotope-Labeled Antibody Standard and Protein Cleavage Isotope Dilution Mass Spectrometry-Reference-Cited by-同舟云学术

Towards Absolute Quantification of Therapeutic Monoclonal Antibody in Serum by LC−MS/MS Using Isotope-Labeled Antibody Standard and Protein Cleavage Isotope Dilution Mass Spectrometry

Published:2008-05-09 Issue:11 Volume:80 Page:4200-4207
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Heudi Olivier¹,Barteau Samuel¹,Zimmer Dieter¹,Schmidt Joerg¹,Bill Kurt¹,Lehmann Natalie¹,Bauer Christian¹,Kretz Olivier¹

Affiliation:

1. DMPK/Bioanalytics, and Biotechnology Development, Novartis Pharma AG, CH-4002 Basel Switzerland

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ac800205s

Reference24 articles.

1. Antibody targeted drugs as cancer therapeutics

2. Recommendations for the Bioanalytical Method Validation of Ligand-Binding Assays to Support Pharmacokinetic Assessments of Macromolecules

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4. Quantification of Small Therapeutic Proteins in Plasma by Liquid Chromatography−Tandem Mass Spectrometry: Application to an Elastase Inhibitor EPI-hNE4

5. Method development for the concentration determination of a protein in human plasma utilizing 96-well solid-phase extraction and liquid chromatography/tandem mass spectrometric detection

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