1. Metabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering and High-Temperature Chemical Processes (ICE-HT), Foundation for Research and Technology-Hellas (FORTH), Patras, GR-26504 Greece, Laboratory of Human and Animal Physiology, Department of Biology, University of Patras, Patras, GR-26500, Greece, and Metabolic Engineering and Systems Biology Laboratory, Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, United States