Synthesis of 9-O-Substituted Derivatives of 9-Hydroxy-5,6-dimethyl-6H- pyrido[4,3-b]carbazole-1-carboxylic Acid (2-(Dimethylamino)ethyl)amide and Their 10- and 11-Methyl Analogues with Improved Antitumor Activity-Reference-Cited by-同舟云学术

Synthesis of 9-O-Substituted Derivatives of 9-Hydroxy-5,6-dimethyl-6H- pyrido[4,3-b]carbazole-1-carboxylic Acid (2-(Dimethylamino)ethyl)amide and Their 10- and 11-Methyl Analogues with Improved Antitumor Activity

Published:1999-06-01 Issue:12 Volume:42 Page:2191-2203
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Guillonneau Claude¹,Pierré Alain¹,Charton Yves¹,Guilbaud Nicolas¹,Kraus-Berthier Laurence¹,Léonce Stéphane¹,Michel André¹,Bisagni Emile¹,Atassi Ghanem¹

Affiliation:

1. Division Chimie A and Division de Cancérologie Expérimentale, Institut de Recherches Servier, 11 rue des Moulineaux, 92150 Suresnes, France, and UMR176 CNRS−Institut Curie-Recherche, Bâtiment 110, 15 rue Georges Clémenceau, 91405 Orsay, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm981093m

Reference27 articles.

1. S16020–2, a New Highly Cytotoxic Antitumor Olivacine Derivative: DNA Interaction and DNA Topoisomerase II Inhibition

2. In vitro cytotoxicity of S16020-2, a new olivacine derivative

3. In vivo antitumor activity of S 16020-2, a new olivacine derivative

4. Experimental Antitumour Activity of S 16020-2 in a Panel of Human Tumours

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