1. Department of Technical Analytical Chemistry, Center for Chemistry and Chemical Engineering, Lund University, P.O.B. 124, S-221 00 Lund, Sweden, Analytical Chemistry, Pharmaceutical R&D, AstraZeneca R&D Mölndal, S-431 83 Mölndal, Sweden, and Pharmaceutical Technology, Pharmaceutical R&D, AstraZeneca R&D Mölndal, S-431 83 Mölndal, Sweden