1. Department of Research and Development, Microbio Company, Ltd., No. 81, Gauyang N. Road, Longtan Shiang, Taoyuan, Taiwan, Republic of China; Department of Biochemistry, College of Medicine, National Taiwan University, No. 1, Sec. 1 Jen-Ai Road, Taipei, Taiwan, Republic of China; and Department of Life Sciences, Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan, Republic of China