Novel Cytochrome P450 Bioactivation of a Terminal Phenyl Acetylene Group: Formation of a One-Carbon Loss Benzaldehyde and Other Oxidative Products in the Presence of N-Acetyl Cysteine or Glutathione-Reference-Cited by-同舟云学术

Novel Cytochrome P450 Bioactivation of a Terminal Phenyl Acetylene Group: Formation of a One-Carbon Loss Benzaldehyde and Other Oxidative Products in the Presence of N-Acetyl Cysteine or Glutathione

Published:2011-03-11 Issue:5 Volume:24 Page:677-686
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Subramanian Raju¹,Tam Janet¹,Aidasani Divesh¹,Reid Darren L.¹,Skiles Gary L.¹

Affiliation:

1. Department of Pharmacokinetics and Drug Metabolism and §Department of Pharmaceutical Research and Development, Amgen Inc., Thousand Oaks, California 91320, United States

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx1004375

Reference16 articles.

1. Selective Inhibitors of the Mutant B-Raf Pathway: Discovery of a Potent and Orally Bioavailable Aminoisoquinoline

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