Development of Scalable Manufacturing Routes to AZD1981. Application of the Semmler–Wolff Aromatisation for Synthesis of the Indole-4-amide Core-Reference-Cited by-同舟云学术

Development of Scalable Manufacturing Routes to AZD1981. Application of the Semmler–Wolff Aromatisation for Synthesis of the Indole-4-amide Core

Published:2012-11-01 Issue:11 Volume:16 Page:1746-1753
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Sulur Manjunatha¹,Sharma Parhalad¹,Ramakrishnan Ravi¹,Naidu Ravi¹,Merifield Eric²,Gill Duncan M.²,Clarke Adrian M.²,Thomson Colin²,Butters Michael³,Bachu Sreekanth¹,Benison Colin H.³,Dokka Nagaraju¹,Fong Emily R.²,Hose David R. J.³,Howell Gareth P.²,Mobberley Siobhan E.²,Morton Simon C.²,Mullen Alexander K.³,Rapai Jayan¹,Tejas Bharathi¹

Affiliation:

1. Pharmaceutical Development, AstraZeneca India Pvt. Ltd., Hebbal, Off Bellary Road, Bangalore 560024, India

2. Pharmaceutical Development, AstraZeneca R & D Charnwood, Bakewell Road, Loughborough, Leicestershire, LE11 5RH, United Kingdom

3. Pharmaceutical Development, AstraZeneca, Charter Way, Macclesfield, SK10 2NA, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op300173z

Reference29 articles.

1. Bonnert, R.; Rasul, R.Novel substituted 3-sulfur indoles. WO 2004106302 A1, 2004.

2. A novel method of indole ring system construction: One-pot synthesis of 4- and 6- nitroindole derivatives via base promoted reaction between 3-nitroaniline and ketones

3. Synthesis of heterocyclic compounds via vicarious nucleophilic substitution of hydrogen

4. Conley, R. T.; Ghosh, S.InMechanisms of Molecular Migrations;Thyagarajan, B. S., Ed.Interscience:New York, 1971; Vol.4, p251.

5. Ainge, D.; Butters, M.; Merifield, E.; Ramakrishnan, R.; Rayapati, R.; Sharma, P.; Thomson, C.Intermeditaes and processes for the preparation of 4-(acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-1-acetic acid. WO2011004182A1, 2011.

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Computer-aided design, synthesis and evaluation of new SARS-CoV-2 Mpro inhibitors based on 1,5,6,7-tetrahydro-4H-indazol-4-one scaffold;Medicinal Chemistry Research;2023-12-11

2. Multicomponent synthesis of 1,5,6,7-tetrahydro-4H-indol-4-one derivatives;Chemistry of Heterocyclic Compounds;2023-12

3. A photochemical dehydrogenative strategy for aniline synthesis;Nature;2020-08-05

4. Synthesis of 3-Oxoisoindoline-1-carboxamides through Sequential Four-Component Ugi Reaction/Oxidative Nucleophilic Substitution of Hydrogen;Synlett;2020-02-13

5. Palladium(II)-Catalyzed C(sp3)–H Activation of N,O-Ketals towards a Method for the β-Functionalization of Ketones;Synlett;2019-02-05