SAR Studies on Tetrahydroisoquinoline Derivatives: The Role of Flexibility and Bioisosterism To Raise Potency and Selectivity toward P-glycoprotein-Reference-Cited by-同舟云学术

SAR Studies on Tetrahydroisoquinoline Derivatives: The Role of Flexibility and Bioisosterism To Raise Potency and Selectivity toward P-glycoprotein

Published:2014-11-20 Issue:23 Volume:57 Page:9983-9994
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Capparelli Elena¹,Zinzi Laura¹,Cantore Mariangela²,Contino Marialessandra¹,Perrone Maria Grazia¹,Luurtsema Gert³,Berardi Francesco¹²,Perrone Roberto¹²,Colabufo Nicola A.¹²

Affiliation:

1. Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari “A. Moro”, via Orabona 4, 70125 Bari, Italy

2. Biofordrug srl, Spin-off dell’Università degli Studi di Bari “A. Moro”, via Orabona 4, 70125 Bari, Italy

3. Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501640e

Reference29 articles.

1. Overcoming multidrug resistance in cancer: 35 years after the discovery of ABCB1

2. ABC Pumps and Their Role in Active Drug Transport

3. Multidrug resistance in cancer: role of ATP–dependent transporters

4. Multidrug resistance (MDR) in cancer

5. Blood-Brain Barrier P-Glycoprotein Function in Neurodegenerative Disease

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