Pd-Catalyzed Direct C–H Bond Functionalization of Spirocyclic σ1 Ligands: Generation of a Pharmacophore Model and Analysis of the Reverse Binding Mode by Docking into a 3D Homology Model of the σ1 Receptor-Reference-Cited by-同舟云学术

Pd-Catalyzed Direct C–H Bond Functionalization of Spirocyclic σ1 Ligands: Generation of a Pharmacophore Model and Analysis of the Reverse Binding Mode by Docking into a 3D Homology Model of the σ1 Receptor

Published:2012-09-10 Issue:18 Volume:55 Page:8047-8065
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Meyer Christina¹,Schepmann Dirk¹,Yanagisawa Shuichi²,Yamaguchi Junichiro²,Dal Col Valentina³,Laurini Erik³,Itami Kenichiro²,Pricl Sabrina³⁴,Wünsch Bernhard¹

Affiliation:

1. Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster, Hittorfstrasse 58-62, D-48149 Münster, Germany

2. Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan

3. Molecular Simulation Engineering (MOSE) Laboratory, Department of Industrial Engineering and Information Technology (DI3), University of Trieste, Via Valerio 10, 34127 Trieste, Italy

4. National Interuniversity Consortium for Material Science and Technology (INSTM), Research Unit MOSE-DEA, University of Trieste, 34127 Trieste, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300894h

Reference105 articles.

1. Full-Length cDNA Sequence of a Progesterone Membrane-Binding Protein from Porcine Vascular Smooth Muscle Cells

2. Purification, molecular cloning, and expression of the mammalian sigma1-binding site.

3. Cloning and Functional Characterization of a σ Receptor from Rat Brain

4. Cloning and Functional Expression of the Human Type 1 Sigma Receptor (hSigmaR1)

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