Why Carba-LNA-Modified Oligonucleotides Show Considerably Improved 3′-Exonuclease Stability Compared to That of the LNA Modified or the Native Counterparts: A Michaelis−Menten Kinetic Analysis-Reference-Cited by-同舟云学术

Why Carba-LNA-Modified Oligonucleotides Show Considerably Improved 3′-Exonuclease Stability Compared to That of the LNA Modified or the Native Counterparts: A Michaelis−Menten Kinetic Analysis

Published:2010-03-12 Issue:7 Volume:75 Page:2341-2349
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Zhou Chuanzheng¹,Chattopadhyaya Jyoti¹

Affiliation:

1. Bioorganic Chemistry Program, Department of Cell and Molecular Biology, Box 581, Biomedical Centre, Uppsala University, SE-751 23 Uppsala, Sweden

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo100170g

Reference53 articles.

1. RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

2. Progress in Antisense Technology

3. RNAi therapeutics: a potential new class of pharmaceutical drugs

4. Chemically modified siRNA: tools and applications

5. Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis

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