Highly Potent Geminal Bisphosphonates. From Pamidronate Disodium (Aredia) to Zoledronic Acid (Zometa)-Reference-Cited by-同舟云学术

Highly Potent Geminal Bisphosphonates. From Pamidronate Disodium (Aredia) to Zoledronic Acid (Zometa)

Published:2002-07-19 Issue:17 Volume:45 Page:3721-3738
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Widler Leo¹,Jaeggi Knut A.¹,Glatt Markus¹,Müller Klaus¹,Bachmann Rolf¹,Bisping Michael¹,Born Anne-Ruth¹,Cortesi Reto¹,Guiglia Gabriela¹,Jeker Heidi¹,Klein Rémy¹,Ramseier Ueli¹,Schmid Johann¹,Schreiber Gerard¹,Seltenmeyer Yves¹,Green Jonathan R.¹

Affiliation:

1. Novartis Pharma Research, Arthritis and Bone Metabolism Therapeutic Area, CH-4002 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm020819i

Reference67 articles.

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2. Fleisch, H.; Russell, R. G. G.; Straumann, F. Effects of pyrophosphate on hydroxyapatite and its implications in calcium homeostatis.Nature1966,212, 901−903. Francis, M. D.; Russell, R. G.; Fleisch, H. Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo.Science1969,165, 1264−1266. Fleisch H. From polyphosphates to bisphosphonates and their role in bone and calcium metabolism. InProgress in Molecular and Subcellular Biology Vol. 23; Schröder, H. C., Müller, W. E. G., Eds.; Springer-Verlag: Berlin, Heidelberg, 1999; pp 197−216.

3. Diphosphonates Inhibit Hydroxyapatite Dissolution in vitro and Bone Resorption in Tissue Culture and in vivo

4. Bisphosphonates: Mechanisms of Action

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