Structure-Based Design of Potent and Selective 2-(Quinazolin-2-yl)phenol Inhibitors of Checkpoint Kinase 2-Reference-Cited by-同舟云学术

Structure-Based Design of Potent and Selective 2-(Quinazolin-2-yl)phenol Inhibitors of Checkpoint Kinase 2

Published:2010-12-27 Issue:2 Volume:54 Page:580-590
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Caldwell John J.¹,Welsh Emma J.¹,Matijssen Cornelis¹,Anderson Victoria E.¹,Antoni Laurent¹,Boxall Kathy¹,Urban Frederique¹,Hayes Angela¹,Raynaud Florence I.¹,Rigoreau Laurent J. M.²,Raynham Tony²,Aherne G. Wynne¹,Pearl Laurence H.³,Oliver Antony W.³,Garrett Michelle D.¹,Collins Ian¹

Affiliation:

1. Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, U.K.

2. Cancer Research Technology Discovery Laboratories London, Wolfson Institute for Biomedical Research, The Cruciform Building, Gower Street, London WC1E 6BT, U.K.

3. Section of Structural Biology, Chester Beatty Laboratories, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101150b

Reference47 articles.

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2. Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

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