Synthesis of 2-(Pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(Pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(Pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a Class of Potent Nicotinic Acetylcholine Receptor

Synthesis of 2-(Pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(Pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(Pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a Class of Potent Nicotinic Acetylcholine Receptor–Ligands

Published:2008-03-26 Issue:9 Volume:73 Page:3497-3507
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Bhatti Balwinder S.¹,Strachan Jon-Paul¹,Breining Scott R.¹,Miller Craig H.¹,Tahiri Persida¹,Crooks Peter A.¹,Deo Niranjan¹,Day Cynthia S.¹,Caldwell William S.¹

Affiliation:

1. Targacept, Inc., 200 East 1st Street, Suite 300, Winston-Salem, North Carolina 27101-4165, College of Pharmacy, Department of Pharmaceutical Sciences, University of Kentucky, Rose Street, Lexington, Kentucky 40536-0082, and Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo800028q

Reference54 articles.

1. Exploring the Nature of Molecular Recognition in Nicotinic Acetylcholine Receptors

2. Broad-Spectrum, Non-Opioid Analgesic Activity by Selective Modulation of Neuronal Nicotinic Acetylcholine Receptors

3. Neuronal Nicotinic Receptor Subtypes: DEFINING THERAPEUTIC TARGETS

4. Neuronal nicotinic acetylcholine receptor ligands as potential analgesics

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