Impact of Chemical Composition on the Nanostructure and Biological Activity of α-Galactosidase-Loaded Nanovesicles for Fabry Disease Treatment

Author:

Tomsen-Melero Judit123ORCID,Passemard Solène13,García-Aranda Natalia34,Díaz-Riascos Zamira Vanessa34,González-Rioja Ramon13ORCID,Nedergaard Pedersen Jannik56ORCID,Lyngsø Jeppe56ORCID,Merlo-Mas Josep2ORCID,Cristóbal-Lecina Edgar37ORCID,Corchero José Luis38ORCID,Pulido Daniel37ORCID,Cámara-Sánchez Patricia34ORCID,Portnaya Irina9,Ionita Inbal9,Schwartz Simó310ORCID,Veciana Jaume13ORCID,Sala Santi2,Royo Miriam37ORCID,Córdoba Alba2ORCID,Danino Dganit911,Pedersen Jan Skov56ORCID,González-Mira Elisabet13ORCID,Abasolo Ibane34ORCID,Ventosa Nora13ORCID

Affiliation:

1. Institut de Ciència de Materials de Barcelona, ICMAB-CSIC, Campus UAB, 08193 Bellaterra, Spain

2. Nanomol Technologies SL, Campus de la UAB, 08193 Bellaterra, Spain

3. Centro de Investigación Biomédica en Red−Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28029 Madrid, Spain

4. Drug Delivery and Targeting, and Functional Validation and Preclinical Research (FVPR), CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, 08035 Barcelona, Spain

5. Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus C, Denmark

6. Department of Chemistry, Aarhus University, Langelandsgade 140, DK-8000 Aarhus C, Denmark

7. Institut de Química Avançada de Catalunya (IQAC-CSIC), 08034 Barcelona, Spain

8. Departament de Genètica i de Microbiologia, Institut de Biotecnologia i de Biomedicina (IBB), Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain

9. CryoEM Laboratory of Soft Matter, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, 32000 Haifa, Israel

10. Drug Delivery and Targeting, CIBBIM-Nanomedicine, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, 08035 Barcelona, Spain

11. Faculty of Biotechnology and Food Engineering, Guangdong Technion-Israel Institute of Technology, Daxue Road, Shantou 515063, Guangdong Province, China

Funder

Centro de Investigaci??n Biom??dica en Red en Bioingenier??a, Biomateriales y Nanomedicina

European Commission

Generalitat de Catalunya

Ministerio de Econom??a y Competitividad

Ministerio de Ciencia e Innovaci??n

Publisher

American Chemical Society (ACS)

Subject

General Materials Science

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