Poly(lactide-co-glycolide) Nanoparticles Mediate Sustained Gene Silencing and Improved Biocompatibility of siRNA Delivery Systems in Mouse Lungs after Pulmonary Administration

Author:

Wu Lan1,Wu Lin-Ping2ORCID,Wu Jingya1,Sun Jin1ORCID,He Zhonggui1,Rodríguez-Rodríguez Cristina34ORCID,Saatchi Katayoun3ORCID,Dailey Lea Ann5,Häfeli Urs O.36ORCID,Cun Dongmei1,Yang Mingshi16ORCID

Affiliation:

1. Wuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road No. 103, Shenyang 110016, People’s Republic of China

2. Drug Discovery Pipeline, Hefei Institute of Stem Cell and Regenerative Medicine, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, People’s Republic of China

3. Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver BC V6T 1Z3, Canada

4. Department of Physics & Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver BC V6T 1Z1, Canada

5. Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstraße 14 (UZA II), Vienna 1090, Austria

6. Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen 2100, Denmark

Funder

Ministry of Science and Technology of the People's Republic of China

European Cooperation in Science and Technology

National Natural Science Foundation of China

Lundbeckfonden

International Science and Technology Cooperation Project of HuangPu

International Science and Technology Cooperation Program of Guangdong Province

Guiding Project for Science and Technology of Liaoning Province

National Science and Technology Major Projects for New Drug Development

Publisher

American Chemical Society (ACS)

Subject

General Materials Science

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