1. Institute of Physiological Chemistry and Pathobiochemsitry, the University at Mainz, Duesbergweg 6, 55099 Mainz, Germany, Institute of Molecular Biotechnology e. V., Beutenbergstrasse 11, 07745 Jena, Germany, Children's Hospital, Department of Clinical Chemistry and Biochemistry, University of Munich, Lindwurmstrasse 4, 80337, Germany, and Institute of Pharmacology and Toxicology, the University at Würzburg, Versbacherstrasse 9, 97078 Würzburg, Germany