Dynamic Combinatorial Selection of Molecules Capable of Inhibiting the (CUG) Repeat RNA−MBNL1 Interaction In Vitro: Discovery of Lead Compounds Targeting Myotonic Dystrophy (DM1)
Author:
Affiliation:
1. Departments of Dermatology, Biochemistry and Biophysics, Chemistry, and Neurology, and The Center for Future Health, University of Rochester, Rochester, New York 14642
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
https://pubs.acs.org/doi/pdf/10.1021/ja804398y
Reference50 articles.
1. Clinical and molecular aspects of the myotonic dystrophies: A review
2. Myotonic dystrophy: RNA-mediated muscle disease
3. Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member
4. Visualization of double-stranded RNAs from the myotonic dystrophy protein kinase gene and interactions with CUG-binding protein
5. Expanded CUG repeat RNAs form hairpins that activate the double-stranded RNA-dependent protein kinase PKR
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