Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a Novel Peripherally Restricted Cannabinoid-1 Receptor Antagonist with Significant Weight-Loss Efficacy in Diet-Induced Obese Mice-Reference-Cited by-同舟云学术

Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a Novel Peripherally Restricted Cannabinoid-1 Receptor Antagonist with Significant Weight-Loss Efficacy in Diet-Induced Obese Mice

Published:2013-12-04 Issue:24 Volume:56 Page:9920-9933
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chang Chun-Ping¹,Wu Chien-Huang¹,Song Jen-Shin¹,Chou Ming-Chen¹,Wong Ying-Chieh¹,Lin Yinchiu¹,Yeh Teng-Kuang¹,Sadani Amit A.¹,Ou Ming-Hung¹,Chen Kun-Hung¹,Chen Pei-Hsuan¹,Kuo Po-Chu¹,Tseng Chen-Tso¹,Chang Kuei-Hua¹,Tseng Shi-Liang¹,Chao Yu-Sheng¹,Hung Ming-Shiu¹,Shia Kak-Shan¹

Affiliation:

1. Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 35053, Taiwan, R.O.C.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401158e

Reference50 articles.

1. Endocannabinoid Signaling in the Brain

2. International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors

3. Cultured Rat Microglial Cells Synthesize the Endocannabinoid 2-Arachidonylglycerol, Which Increases Proliferation via a CB2Receptor-Dependent Mechanism