Isolation and Synthesis of Novel Farnesyl Protein Transferase Inhibitors, Valinoctins A and B, from Streptomyces Strain MJ858-NF3-Reference-Cited by-同舟云学术

Isolation and Synthesis of Novel Farnesyl Protein Transferase Inhibitors, Valinoctins A and B, from Streptomyces Strain MJ858-NF3

Published:1996-01-01 Issue:3 Volume:59 Page:232-236
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Sekizawa Ryuichi¹,Iinuma Hironobu¹,Muraoka Yasuhiko¹,Naganawa Hiroshi¹,Kinoshita Naoko¹,Nakamura Hikaru¹,Hamada Masa¹,Takeuchi Tomio¹,Umezawa Kazuo¹

Affiliation:

1. Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223, Japan, and Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/np960067t

Reference15 articles.

1. Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.

2. Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

3. Lining up the evidence

4. Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites.

5. Identification of Ras farnesyltransferase inhibitors by microbial screening.

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