Novel α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate (AMPA) Receptor Antagonists of 2,3-Benzodiazepine Type: Chemical Synthesis, in Vitro Characterization, and in Vivo Prevention of Acute Neurodegeneration-Reference-Cited by-同舟云学术

Novel α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate (AMPA) Receptor Antagonists of 2,3-Benzodiazepine Type: Chemical Synthesis, in Vitro Characterization, and in Vivo Prevention of Acute Neurodegeneration

Published:2005-06-21 Issue:14 Volume:48 Page:4618-4627
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Elger Bernd¹,Huth Andreas¹,Neuhaus Roland¹,Ottow Eckard¹,Schneider Herbert¹,Seilheimer Bernd¹,Turski Lechoslaw¹

Affiliation:

1. Schering AG, 13342 Berlin, Germany, and Solvay Pharmaceuticals Research Laboratories, C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0580003

Reference30 articles.

1. Pathobiology of ischaemic stroke: an integrated view

2. Multiple Sclerosis and Glutamate

3. GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses

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