1. Shanghai Office, Shionogi & Co., Ltd., 306A, 3F, Building A, Far East International Plaza, No. 319, Xianxia Road, Shanghai 200051, China, Discovery Research Laboratories, Shionogi & Co., Ltd., 12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan, and CMC Development Laboratories, Shionogi & Co., Ltd., 1-3, Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan