Novel Orally Bioavailable γ-Secretase Inhibitors with Excellent in Vivo Activity-Reference-Cited by-同舟云学术

Novel Orally Bioavailable γ-Secretase Inhibitors with Excellent in Vivo Activity

Published:2009-05-11 Issue:11 Volume:52 Page:3441-3444
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Keown Linda E.¹,Collins Ian¹,Cooper Laura C.¹,Harrison Timothy¹,Madin Andrew¹,Mistry Jayesh¹,Reilly Michael¹,Shaimi Mohamed¹,Welch Christopher J.¹,Clarke Earl E.¹,Lewis Huw D.¹,Wrigley Jonathan D. J.¹,Best Jonathan D.¹,Murray Fraser¹,Shearman Mark S.¹

Affiliation:

1. Departments of Medicinal Chemistry, Molecular and Cellular Neuroscience, and in Vivo Neuroscience, The Neuroscience Research Centre, Merck Sharp & Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex, CM20 2QR, U.K., and Department of Process Research, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900056p

Reference14 articles.

1. Alzheimer's Disease

2. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

3. Memapsin 2 (Beta-Secretase) Inhibitors: Drug Development

4. A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core

Cited by 24 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Convergent synthesis of thiodiazole dioxides from simple ketones and amines through an unusual nitrogen-migration mechanism;Chemical Science;2024

2. Identification of binding sites in nicastrin and binding modes of its inhibitors;F1000Research;2023-02-09

3. Cinchonidine-Catalyzed Synthesis of Oxazabicyclo[4.2.1]nonanones from N-Aryl-α,β-unsaturated Nitrones and 1-Ethynylnaphthalen-2-ols;Organic Letters;2022-06-06

4. Organocatalytic Enantioselective [8+4] Cycloadditions of Isobenzofulvenes for the Construction of Bicyclo[4.2.1]nonanes;Chinese Journal of Chemistry;2021-09-23

5. 1,2,5-Thiadiazole Scaffold: A review on recent progress in biological activities;Combinatorial Chemistry & High Throughput Screening;2021-06-22